Giovanni Ligresti

Lymphatic ERG Governs Junctional Plasticity and Fluid Clearance via an EDNRB Signaling Axis in Pulmonary Fibrosis

This study identifies ERG-EDNRB signaling in lymphatic endothelial cells as critical for junctional plasticity and fluid clearance in pulmonary fibrosis, showing that its disruption protects against fibrosis.

Targeting hypoxia-responsive miR-155-5p and miR-210-3p restores alveolar regeneration and reverses pulmonary fibrosis

This study identifies miR-155-5p and miR-210-3p as regulators of alveolar regeneration in IPF, showing their inhibition restores epithelial repair and reverses fibrosis in mice.

ACKR1-expressing venous endothelial cells establish a pro-fibrotic niche in pulmonary fibrosis

The paper identifies ACKR1-expressing venous endothelial cells as key drivers of fibrosis in IPF and shows ACKR1 inhibition reduces fibrosis in vivo.

Mosaic pattern: lung functional heterogeneity at the alveolus level

This study observes a mosaic pattern of aerosol distribution in alveoli across species and ages, revealing functional heterogeneity in lung deposition and its implications for disease and therapy.

A Simultaneous Inhibition of ID1 and ID3 Protects Against Pulmonary Fibrosis

This study shows that inhibiting both ID1 and ID3 reduces pulmonary fibrosis in mice and human cells by blocking fibroblast proliferation and differentiation.