Engineering highly multivalent sperm-binding IgG antibodies for potent non-hormonal female contraception
Bhawana Shrestha, Alison Schaefer, Jamal I. Saada, Yong Zhu, Timothy M. Jacobs, Elizabeth C. Chavez, Stuart S. Omsted, Kathleen L. Vincent, Thomas R. Moench, Samuel K. Lai
The paper engineers multivalent IgG antibodies that agglutinate sperm more potently than monovalent IgGs, achieving high contraceptive efficacy in sheep.
bioRxiv · Apr 22, 2020 · PreprintMolecular Biology