Author

Samuel K. Lai

University of North Carolina at Chapel HillORCID 0000-0003-4721-528XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:multiple species· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alison SchaeferiD· 2 shared Bhawana ShresthaiD· 2 shared Elizabeth C. ChaveziD· 2 shared Thomas R. MoenchiD· 2 shared Timothy M. JacobsiD· 2 shared Alexander J. Kopp· 1 shared Jamal I. SaadaiD· 1 shared Jamie D Liu· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Alison SchaeferORCID

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3 papers

Recent·Most cited

MicrobiologyAnnals of Biomedical EngineeringPeer-reviewedMay 17, 2026

A Droplet Digital PCR Assay for Quantification of Bacteriophage Viral Vector Titer and Purity.

Peter J. Voorhees, Ronni M Ponek, Jamie D Liu, Samuel K. Lai

This paper presents an optimized ddPCR assay to quantify phage vector titer and purity, showing improved accuracy and precision compared to biological activity assays.

DOI 10.1007/s10439-026-04117-6

bacteria (other)DNA methylation

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Molecular BiologybioRxivPreprintApr 27, 2020

Engineering Highly Homogenous Tetravalent IgGs with Enhanced Sperm Agglutination Potency

Bhawana Shrestha, Alison Schaefer, Elizabeth C. Chavez…·Samuel K. Lai

The paper designs tetravalent anti-sperm IgGs with enhanced agglutination potency compared to the parent IgG, while maintaining production yields and thermostability.

DOI 10.1101/2020.04.27.064865

humanprotein structure

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Molecular BiologybioRxivPreprintApr 22, 2020

Engineering highly multivalent sperm-binding IgG antibodies for potent non-hormonal female contraception

Bhawana Shrestha, Alison Schaefer, Jamal I. Saada…·Samuel K. Lai

The paper engineers multivalent IgG antibodies that agglutinate sperm more potently than monovalent IgGs, achieving high contraceptive efficacy in sheep.

1 citation

humanmultiple species

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