Genetic code expansion enables programmable covalent protein design
Helena de Puig, Erkin Kuru, Michaël Moret, Allison Flores, Suneesh Karunakaran, Dinara Sayfullina, Subhrajit Rout, Carmen Escobedo‐Lucea, James J. Collins, George McDonald Church
This paper introduces AminoX, a platform for programmable covalent protein design using non-standard amino acids, enabling efficient screening and functional validation of covalent warheads and multifunctional proteins.
bioRxiv · May 16, 2026 · PreprintSynthetic Biology