Identification of novel cis-acting elements, E-box and ISRE, regulating IFNγ-IRF1 axis-mediated NLRC5 expression
Ji‐Seung Yoo, Yusuke Kasuga, Saptha Vijayan, Suhail Yousuf, Koichi S. Kobayashi
This study identifies two novel cis-regulatory elements and IRF1 as a regulator of NLRC5, revealing how viral factors inhibit IFNγ-mediated MHC class I pathway.
bioRxiv · Feb 20, 2025 · PreprintImmunology