Potent and selective repression of SCN9A by engineered zinc finger repressors for the treatment of neuropathic pain
Mohammad Samie, Toufan Parman, Mihika Jalan, Jisoo Lee, Patrick J. Dunn, Jason A. Eshleman, Dianna Baldwin Vidales, Josh Holter, Brian Jones, Yonghua Pan, Marina Falaleeva, Sarah J. Hinkley, Alicia Goodwin, Tammy Chen, Sumita Bhardwaj, , Amy M. Pooler
This study demonstrates the use of engineered zinc finger repressors delivered via AAV to reduce SCN9A expression in preclinical models, showing efficacy in reducing neuropathic pain.
bioRxiv · Sep 6, 2024 · PreprintNeuroscience