Author

Supriya Sen

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander HoffmanniD· 2 shared Adewunmi AdelajaiD· 1 shared Apeksha SinghiD· 1 shared Julian GonzaleziD· 1 shared Michael Iter· 1 shared Stefanie LueckeiD· 1 shared Xiaolu GuoiD· 1 shared Xiaolu GuoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersSystems Biology

Alexander HoffmannORCID

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2 papers

Recent·Most cited

Macrophages maintain signaling fidelity in response to ligand mixtures

Xiaolu Guo, Supriya Sen, Julian Gonzalez, Alexander Hoffmann

This paper shows macrophages maintain stimulus-response specificity through NFκB signaling even when exposed to multi-ligand mixtures, using mathematical modeling and live-cell experiments.

bioRxiv · Mar 27, 2025 · PreprintSystems Biology

Stimulus-Response signaling dynamics characterize macrophage polarization states

Apeksha Singh, Supriya Sen, Michael Iter, Adewunmi Adelaja, Stefanie Luecke, Xiaolu Guo, Alexander Hoffmann

This study characterizes macrophage polarization states by analyzing NFκB signaling dynamics in response to different stimuli, revealing a multi-dimensional polarization landscape rather than a simple M1/M2 dichotomy.

Cell Systems · Jun 1, 2024Peer-reviewedSystems Biology