Xiaolu Guo

Reconstructing Noisy Gene Regulation Dynamics UsingExtrinsic-Noise-Driven Neural Stochastic Differential Equations

This paper introduces an END-nSDE framework to reconstruct noisy gene regulation dynamics from heterogeneous cell populations, outperforming RNNs and LSTMs in modeling extrinsic noise effects.

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signaling

This study develops a computational workflow to assess drug effects on NFκB signaling dynamics, finding that temporal coding capacity is robust to pharmacological perturbations.

Macrophages maintain signaling fidelity in response to ligand mixtures

This paper shows macrophages maintain stimulus-response specificity through NFκB signaling even when exposed to multi-ligand mixtures, using mathematical modeling and live-cell experiments.

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

The paper develops a mathematical model to uncover the nonequilibrium mechanism behind drug synergy between Activators and Noise Enhancers in HIV latency reactivation.