X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels
Ryan Allsop, Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Suresh Poovanthingal, Wilfred F. J. van IJcken, Jeroen Demmers, Hegias Mira-Bontenbal, Cristina Gontan, Joost H. Gribnau, Vincent Pasque
The paper shows that X-chromosome upregulation occurs gene-by-gene at both RNA and protein levels in mouse pluripotent stem cells.
Nature Communications · Sep 30, 2025Peer-reviewedDevelopmental Biology