Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype
Pierre Ellul, Gwladys Fourcade, Vanessa Mhanna, Nicolas Coatnoan, Susana Bodula, Danielle Seilhean, Laura Mouton, Gwendolyn Marguerit, Richard Delorme, Mi Tian, Ben Youngblood, Michèlle Rosenzwajg, Nicolas Tchitchek, David Klatzmann
Maternal immune activation causes Treg deficiency in offspring, leading to brain inflammation and autism-like behaviors, which can be reversed by Treg stimulation.
bioRxiv · Jan 6, 2025 · PreprintImmunology