Gwladys Fourcade

The paper identifies sex-specific differences in TCR selection during thymic development, showing female effector T cells have more autoimmunity-associated TCRs while female Tregs have fewer.

This study shows IL-1β signaling affects Tfh and Tfr cells in human lymphoid tissues, linking it to autoantibody production and autoimmune disease.

Maternal immune activation causes Treg deficiency in offspring, leading to brain inflammation and autism-like behaviors, which can be reversed by Treg stimulation.

This study shows that IL-1R2 on Tfr cells prevents excessive activation and allergy by limiting IgE and promoting IgG responses.