In Vivo Mutagenesis of a Ketosynthase Domain Uncovers Productivity and Specificity Control in Modular Polyketide Synthases
Jingyi Hu, Susanna Kushnir, Marius Brandenburger, Frank Schulz
The paper identifies active-site motifs in a ketosynthase domain that control productivity and specificity in polyketide synthases through in vivo mutagenesis and structural analysis.
bioRxiv · Sep 26, 2025 · PreprintBiochemistry