A general approach to reduce off-target radioactivity in vivo via Tetrazine-Knock-Out (TKO)
Swarbhanu Sarkar, Jonathan M. Pham, Kimberly J. Edwards, Nitika Sharma, Kexiang Xu, A. Paden King, Andres Fernandez del Castillo, Michael D. Farwell, Daniel A. Pryma, Stephen J. Schuster, Mark A. Sellmyer
This paper develops a method to rapidly clear radioactivity from blood using a tetrazine-knock-out (TKO) approach, improving imaging contrast and reducing radiation exposure.
bioRxiv · May 30, 2024 · PreprintBioengineering