Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification
Parya Behzadi, Andrew A. Wendling, Rolando A. Cuevas, Alex Crane, Claire C. Chu, William J. Moorhead, Ryan Wong, Mark J. Brown, Joshua Tamakloe, Swathi Suresh, Payam Salehi, Iris Zamir Jaffe, Allison L. Kuipers, Lyudmila Lukashova, Konstantinos Verdelis, Cynthia St. Hilaire
This study shows rapamycin reduces arterial mineral density and improves vascular structure in Mgp-/- mice with medial arterial calcification, though calcification volume remains unchanged.
American Journal of Physiology-Heart and Circulatory Physiology · May 8, 2025Peer-reviewedPhysiology