DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death
Poulami Ghosh, Shivani Krishna Kapuganti, Sabhyata M. Gopal, Vhasnsciani A R, Swati Lamba, Purusharth I Rajyaguru, Sannula Kesavardhana
This paper shows that DDX3X syndrome mutations cause solid-like stress granules and neuronal death by altering DDX3X-RNA conformation.
Human Molecular Genetics · Jan 1, 2026Peer-reviewedBiochemistry