DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death
Poulami Ghosh, Shivani Krishna Kapuganti, Sabhyata M. Gopal…·Sannula Kesavardhana
This paper shows that DDX3X syndrome mutations cause solid-like stress granules and neuronal death by altering DDX3X-RNA conformation.