Dual orexin antagonist DORA-22 suppressed posttraumatic seizures and enhances GABAergic inhibition in dentate granule cells
Sruthi R Konduru, Jesse R. Isaacson, Zihao Zhou, Rohan K. Rao, Danny J. Lasky, Swati S. Vattem, Sophie J. Rewey, Mathew V. Jones, Rama K. Maganti
This study shows that DORA-22 treatment reduces posttraumatic seizures and restores sleep homeostasis after traumatic brain injury.
bioRxiv · Apr 17, 2022 · PreprintNeuroscience