Mycobacterium tuberculosis inhibits autocrine type I interferon signaling to increase intracellular survival.
Dallas A. Banks, Sarah E. Ahlbrand, V. Keith Hughitt, Swati Shah, Stefanie N. Vogel, Najib M. El-Sayed, Volker Briken
This study shows Mycobacterium tuberculosis inhibits IFN-β signaling in macrophages to enhance its survival by reducing phosphorylation of JAK1, TYK2, STAT1, and STAT2.
bioRxiv · Sep 26, 2018 · PreprintMicrobiology