Najib M. El-Sayed

This study shows that deleting the pknF gene in Mycobacterium tuberculosis increases its virulence in mice by enhancing production of the pro-virulence lipid PDIM and reducing host survival.

The paper investigates immune variation in greater spear-nosed bats, finding male-biased immune ageing and stronger inflammatory responses in males and older bats.

This study shows melanopsin regulates local axonal translation in developing ipRGCs, affecting circuit assembly and synaptic development before eye-opening.

This paper identifies genetic determinants in Pseudomonas aeruginosa linking redox metabolism to alginate biosynthesis by analyzing RNA sequencing data and mutant strains.

This study shows that naturally resistant L. (V.) panamensis strains induce distinct macrophage responses compared to sensitive strains, even in the presence of antimony, highlighting host-parasite interactions in drug resistance.

The paper introduces da_Tracker, an automated workflow for high-throughput single-cell and single-phagosome tracking in infected cells, enabling quantitative analysis of pathogen-host interactions.

This study shows that macrophage metallothioneins (MTs) are involved in antileishmanial activity of antimonials by detoxifying xenobiotics and enhancing parasite killing.

The paper investigates how PIWI and retrotransposon nimbus interact to modulate resistance to Schistosoma mansoni in Biomphalaria glabrata snails through epigenetic mechanisms.

The paper identifies a T. cruzi zinc finger protein, TcZC3H12, that regulates epimastigote gene expression and negatively affects metacyclogenesis.

This study shows Mycobacterium tuberculosis inhibits IFN-β signaling in macrophages to enhance its survival by reducing phosphorylation of JAK1, TYK2, STAT1, and STAT2.