The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling
Blake J. Laham, Sahana S. Murthy, Monica Hanani, Mona Clappier, Sydney Boyer, Betsy Vasquez, Elizabeth Gould
This study shows that early-life adversity in female mice increases avoidance behavior during diestrus, linked to progesterone and allopregnanolone signaling, with ovariectomy and receptor antagonism affecting these behaviors.
Nature Communications · Dec 7, 2022Peer-reviewedNeuroscience