Blake J. Laham

Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

This study shows adult-born granule cells in the hippocampus are necessary for retrieving remote developmental memories of the mother in adult mice.

Activation of the CA2-vCA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

This study shows that activating the CA2-vCA1 pathway in Shank3B knockout mice restores social recognition function, suggesting potential therapeutic targets for social memory deficits.

The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

This study shows that early-life adversity in female mice increases avoidance behavior during diestrus, linked to progesterone and allopregnanolone signaling, with ovariectomy and receptor antagonism affecting these behaviors.

Estradiol-induced progesterone synthesis develops post-puberty in the rostral hypothalamus and coincides with post-pubertal changes in the steroidogenic pathway in female mouse hypothalamic astrocytes

This study shows that estradiol-induced progesterone synthesis in the rostral hypothalamus develops post-puberty in female mice and correlates with increased membrane ER expression in hypothalamic astrocytes.