Elizabeth Gould

Maternal deprivation impairs social recognition by diminishing the number of adult-born granule cells in the dentate gyrus

This study shows maternal deprivation reduces adult-born granule cells in male mice, impairing social recognition, which can be reversed by enriched environments or abGC activation.

Developmental scarcity induces sex differences in social recognition and CA2 perineuronal nets

This study shows that developmental scarcity affects social recognition differently in male and female mice, with male-specific changes in CA2 perineuronal nets that can be reversed by matrix degradation.

Developmental CA2 perineuronal net reduction restores social memory in Shank3 mutant mice

This study shows that reducing perineuronal nets in the hippocampal CA2 region of Shank3 mutant mice restores social memory during development and into adulthood.

Adult-born granule cells modulate CA2 network activity during retrieval of developmental memories of the mother

This study shows adult-born granule cells in the hippocampus are necessary for retrieving remote developmental memories of the mother in adult mice.

Activation of the CA2-vCA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

This study shows that activating the CA2-vCA1 pathway in Shank3B knockout mice restores social recognition function, suggesting potential therapeutic targets for social memory deficits.

The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

This study shows that early-life adversity in female mice increases avoidance behavior during diestrus, linked to progesterone and allopregnanolone signaling, with ovariectomy and receptor antagonism affecting these behaviors.