Identification of a key residue in the cellular transcription factor BCL11b important for its global acetylation and its nuclear localization
Laure Vreux, Caroline Vanhulle, Mathilde Galais, Sylvain Fauquenoy, Estelle Plant, Thomas Loustau, Maxime Bellefroid, Gwenaëlle Robette, Maryam Bendoumou, Marion Santangelo, Valérie Martinelli, Christian Schwartz, Ruddy Wattiez, David Communi, Olivier Rohr, Carine M. Van Lint
This study identifies lysine K686 as critical for BCL11b acetylation and nuclear localization, affecting its transcriptional activity and interactions with p300.
bioRxiv · Jan 20, 2026 · PreprintMolecular Biology