Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1
Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos, Aurelio A. Teleman, Johannes Backs, Peter P. Nawroth, Thomas Henry Fleming
This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.
bioRxiv · Apr 9, 2020 · PreprintMolecular Biology