Alireza Saadatmand

The paper identifies CAMK2-NR4A1 signaling as a driver of metabolic substrate switching in heart failure with reduced ejection fraction, linking it to cardiac dysfunction through glucose utilization and lipid depletion.

This study shows that somatic HDAC4-902fs mutations cause loss of HDAC4 function via nonsense-mediated mRNA decay, leading to premature ossification and early death in mice.

This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.