Aurelio A. Teleman

Stress induces DCP2 translation via a stalling-dependent mechanism

The paper identifies DCP2 as an ISR-induced transcript whose translation is regulated by an overlapping ORF that acts as an inhibitory element, which is relieved during stress.

ATM-dependent RHEB phosphorylation couples DNA damage to lysosomal mTORC1 signaling to orchestrate the cellular response to genotoxic stress

The paper identifies ATM-dependent RHEB phosphorylation as a mechanism linking DNA damage to lysosomal mTORC1 signaling, which regulates TFEB and lysosome biogenesis during genotoxic stress.

The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity

This study identifies CYLD as a deubiquitinase that inhibits mTOR activity by removing K63-linked ubiquitin chains, linking its loss to mTOR hyperactivation and disease.

Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

This study investigates the role of eIF2A in translation initiation and uORF-mediated control in HeLa cells using ribosome profiling and luciferase assays, finding no detectable role in initiation.

An in vitro assay of MCTS1-DENR-dependent re-initiation and ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2D

The paper develops an in vitro re-initiation assay and uses ribosome profiling to show that MCTS2 and eIF2D have distinct roles in uORF-dependent translation.

Expression dynamics of long non-coding RNAs during imaginal disc development and regeneration in Drosophila

The paper identifies lncRNAs involved in Drosophila imaginal disc development and regeneration, showing that CR40469 is essential for wing regeneration and can be partially compensated by CR34335.

Niche signalling regulates eIF3d1 phosphorylation to promote distinct modes of translation initiation in stem and differentiating cells

The paper shows that niche signals regulate eIF3d1 phosphorylation to control translation initiation in stem and differentiating cells, enabling distinct translational programs.

Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome

The paper identifies 218 C16:0-acylated and 308 C18-lipid-acylated proteins, showing widespread competition for acylation across the proteome.

PRRC2 proteins regulate translation initiation by promoting leaky scanning

This study identifies PRRC2 proteins as regulators of leaky scanning during translation initiation, enhancing translation of mRNAs with upstream open reading frames.

Phosphorylation of Ribosomal Protein S6 differentially affects mRNA translation based on ORF length

The paper shows that RPS6 phosphorylation decreases during mRNA translation, affecting translation efficiency more for short CDS mRNAs than long ones.

Autonomous termination of proliferation in the Drosophila wing disc is TORC1 dependent

The paper shows that proliferation termination in Drosophila wing discs occurs due to reduced TORC1 activity, independent of Dpp or Hippo/Yorkie signaling.

Selective 40S footprinting reveals that scanning ribosomes remain cap-tethered in human cells

This paper introduces selective 40S footprinting to study translation initiation in human cells, revealing that scanning ribosomes remain cap-tethered and only one ribosome scans a 5UTR at a time.

Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.

Gene expression atlas of a developing tissue by single cell expression correlation analysis

The paper develops a new method for analyzing scRNA-seq data based on gene expression correlations to generate a gene expression atlas of the Drosophila wing disc, identifying 824 genes with spatially restricted expression patterns.

Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability

The paper identifies dZDHHC8 as a palmitoyltransferase in Drosophila that palmitoylates scribble and Ras64B, leading to tissue overgrowth and larval lethality.

Sorting & Sequencing Flies By Size: Identification Of Novel TOR Regulators And Parameters For Successful Sorting

The paper describes a sort-and-sequence experiment to identify TOR regulators by selecting flies for wing length, finding novel regulators and parameters to improve experimental reliability.