Author

Thomas Henry Fleming

Heidelberg UniversityORCID 0000-0002-3232-4515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexandra MoraruiD· 1 shared Alireza SaadatmandiD· 1 shared Anke Tappe‐TheodoriD· 1 shared Anna A DePaoli-RoachiD· 1 shared Anna M. HagenstoniD· 1 shared Asha ParmariD· 1 shared Aurelio A. TelemaniD· 1 shared Daniel WehneriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Alexandra MoraruORCID

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3 papers

Recent·Most cited

Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish

Nora John, Thomas Henry Fleming, Julia Kolb, Olga Lyraki, Sebastián Vásquez-Sepúlveda, Asha Parmar, Kyoohyun Kim, Maria Tarczewska, Pooja Gupta, Kanwarpal Singh, Fédérico Marini, Sumeet Pal Singh, Sven Falk, Kristian Franze, Jochen R. Guck, Daniel Wehner

Dedifferentiated fibroblasts sequentially induce and resolve neutrophil-driven inflammation through cytokine release to facilitate axon regeneration after spinal cord injury in zebrafish.

bioRxiv · Jan 27, 2025 · PreprintNeuroscience

Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain

Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Hagen Wende, Katrin Schrenk-Siemens, Anna A DePaoli-Roach, Anna M. Hagenston, Anke Tappe‐Theodor, Manuela Simonetti, Rohini Kuner, Thomas Henry Fleming, Jan Siemens

This study shows that spinal astrocytic glycogen dynamics, regulated by PTG, are critical for maintaining persistent pain through neuronal plasticity and metabolic coupling with neurons.

bioRxiv · Dec 3, 2022 · PreprintNeuroscience

Phosphorylation of Threonine 107 by Calcium/Calmodulin dependent Kinase II δ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

Jakob Morgenstern, Sylvia Katz, Jutta Krebs-Haupenthal, Jessy Chen, Alireza Saadatmand, Fabiola Garcia Cortizo, Alexandra Moraru, Johanna Zemva, Marta Campos, Aurelio A. Teleman, Johannes Backs, Peter P. Nawroth, Thomas Henry Fleming

This study shows that phosphorylation of threonine 107 in Glo1 by CamKIIδ increases its catalytic efficiency and reduces proteasomal degradation, enhancing MG detoxification.

bioRxiv · Apr 9, 2020 · PreprintMolecular Biology