BiophysicsbioRxivPreprint
The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor
Divya Pathak, T Ozturk Dalpe, Aminah Dawood…·Kathleen M. Ruppel
This paper studies the G768R mutation in cardiac myosin, showing it increases the duty ratio to >60%, leading to hypercontractility and impaired relaxation.
DOI 10.64898/2026.06.02.729673