TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancer
H. H. Workel, J. M. Lubbers, R. Arnold, T. M. Prins, P. van der Vlies, K. de Lange, T. Bosse, I. C. van Gool, F. A. Eggink, M. C. Wouters, F. L. Komdeur, C. L. Creutzberg, A. Kol, A. Plat, M. Glaire, , M. de Bruyn
This study identifies CD8+ T cells as a new source of CXCL13, which contributes to tertiary lymphoid structure formation in tumors through TGF-β signaling.
bioRxiv · Apr 18, 2018Immunology