T. Bottiglieri

A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and alleviates experimental atherosclerosis

This study shows that a very-low carbohydrate high-fat diet (KD) reduces atherosclerosis in mice by altering the plasma metabolome and reducing inflammation.

Ischemic stroke and dietary vitamin B12 deficiency in old-aged females impaired motor function, increased ischemic damage size, and changed metabolite profiles in brain and cecum tissue

This study shows that vitamin B12 deficiency in aged female mice worsens stroke outcomes by increasing brain damage and impairing motor function through apoptosis and mitochondrial metabolic changes.