SARS-CoV-2 Spike evolution influences GBP and IFITM sensitivity
D. Mesner, A.-K. Reuschl, M. V. X. Whelan, T. Bronzovich, T. Haider, L. G. Thorne, G. J. Towers, C. Jolly
This study shows that SARS-CoV-2 variants differ in their sensitivity to GBP and IFITM restriction factors, with Omicron uniquely restricted by these factors due to changes in its spike protein.
bioRxiv · Mar 7, 2022 · PreprintMicrobiology