Molecular Basis of Antibiotic Self-Resistance in a Bee Larvae Pathogen
T. Dang, B. Loll, S. Müller, R. Skobalj, J. Ebeling, T. Bulatov, S. Gensel, J. Göbel, M. Wahl, E. Genersch, A. Mainz, R. D. Süssmuth
The paper identifies PamZ as a self-resistance factor in Paenibacillus larvae that deactivates paenilamicin by N-acetylation and elucidates its crystal structure.
Nature Communications · Apr 29, 2022Peer-reviewedBiochemistry