T. Dang

Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.

Directed Biosynthesis of Mitragynine Stereoisomers

This study identifies the biosynthetic pathway for mitragynine and related alkaloids and uses it to enzymatically produce mitragynine, its epimer, and fluorinated analogues.

The Arabidopsis INNER NO OUTER (INO) gene acts exclusively and quantitatively in regulation of ovule outer integument development

This study shows that the INO gene quantitatively regulates outer integument development in Arabidopsis ovules through its protein activity levels.

A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase

This study identifies a water-soluble fraction of royal jelly that reduces squalene epoxidase expression in liver cells, thereby lowering cholesterol levels.

Arbuscular mycorrhizal fungal composition across US citrus orchards, management strategies, and disease severity spectrum

The paper assesses how geographical location, management strategies, and disease severity affect arbuscular mycorrhizal fungal communities in citrus root systems across US orchards.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

Molecular Basis of Antibiotic Self-Resistance in a Bee Larvae Pathogen

The paper identifies PamZ as a self-resistance factor in Paenibacillus larvae that deactivates paenilamicin by N-acetylation and elucidates its crystal structure.

Nature of active forces in tissues: how contractile cells can form extensile monolayers

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

This study investigates stemness traits in ovarian surface epithelium and finds that stemness is context-specific and not consistently linked to specific signaling pathways or a single population.

A Novel Standalone Microfluidic Device for Local Control of Oxygen Tension for Intestinal-Bacteria Interactions

This paper introduces a microfluidic device that creates a dual-oxygen environment for studying intestinal epithelial and bacterial interactions without external chambers.

Myosin II isoforms play distinct roles in adherens junction biogenesis

This study identifies distinct roles of myosin II isoforms in adherens junction biogenesis, showing NMIIA provides mechanical force for junction maintenance while NMIIB facilitates E-cadherin clustering and anisotropic stress.