Author

T. de Lange

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:chromatin & epigenetic regulation· 4 Organism:human· 4 Assay:DNA methylation· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. Walz· 3 shared E. Nudler· 2 shared H. Takai· 2 shared J. C. Zinder· 2 shared S. W. Cai· 2 shared V. Svetlov· 2 shared B. T. Chait· 1 shared C. G. Kinzig· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

T. Walz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CST--Polymeraseα-primase solves a second telomere end-replication problem

H. Takai, V. Aria, P. Borges, J. T. P. Yeeles, T. de Lange

The paper identifies a second telomere end-replication problem caused by incomplete duplication of the C-rich strand, solved by CST-Polymeraseα-primase fill-in synthesis.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

POT1 recruits and regulates CST-Polα/Primase at human telomeres

S. W. Cai, H. Takai, T. Walz, T. de Lange

This study determines the structure of human CST bound to POT1/TPP1, revealing how POT1 recruits and regulates CST-Polα/Primase at telomeres through phosphorylation-dependent interactions.

bioRxiv · May 8, 2023Biophysics

Neotelomere formation by human telomerase

C. G. Kinzig, G. Zakusilo, K. K. Takai, T. de Lange

This study shows telomerase can add telomeric repeats to DNA breaks, forming neotelomeres, which may contribute to genome instability and tumorigenesis.

bioRxiv · Oct 31, 2022 · PreprintCancer Biology

Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

J. C. Zinder, P. D. B. Olinares, V. Svetlov, M. W. Bush, E. Nudler, B. T. Chait, T. Walz, T. de Lange

This study characterizes the structural architecture and conformational variability of the human shelterin complex using multiple biophysical methods.

bioRxiv · Jan 24, 2022Biochemistry

Cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state

S. W. Cai, J. C. Zinder, V. Svetlov, M. Bush, E. Nudler, T. Walz, T. de Lange

The paper presents a cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state, revealing its architecture and informing on disease mutations.

bioRxiv · Dec 17, 2021Biochemistry

ATR repression at telomeres by POT1a and POT1b: RPA exclusion and interference by CST

K. Kratz, T. de Lange

The paper shows POT1a represses ATR at telomeres by excluding RPA, while POT1b is less effective due to its interaction with CST/Pol/primase.

bioRxiv · Jun 24, 2018Cell Biology