Author

T. Dijkstra

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Biology Disciplines

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Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. N. Lupas· 1 shared L. Weidmann· 1 shared O. Kohlbacher· 1 shared S. Lederer· 1 shared T. Heskes· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 4 mutual co-author links

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1 shared paperEvolutionary Biology

A. N. Lupas

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2 papers

Recent·Most cited

Minor deviations from randomness have huge repercussions on the functional structuring of sequence space

L. Weidmann, T. Dijkstra, O. Kohlbacher, A. N. Lupas

The paper compares the distribution of natural protein sequences to random models, finding that natural sequences are largely random in global sequence space when accounting for amino acid composition.

bioRxiv · Jun 27, 2021 · PreprintEvolutionary Biology

Additive Dose Response Models: Defining Synergy

S. Lederer, T. Dijkstra, T. Heskes

The paper introduces an improved method for measuring synergy in compound combinations by comparing measured responses to expected non-interactive responses using the Explicit Mean Equation.

bioRxiv · Jul 31, 2019Pharmacology & Toxicology