Author

O. Kohlbacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Marcu· 2 shared H. Schuster· 2 shared L. Bichmann· 2 shared S. Stevanovic· 2 shared A. Franke· 1 shared A. Immel· 1 shared A. N. Lupas· 1 shared A. Nebel· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

A. Marcu

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Author profile →

5 papers

Recent·Most cited

Cross-linking of the Endolysosomal System Reveals Flotillin Structures and Putative Cargo

J. Singh, H. Elhabashy, P. Muthukottiappan, M. Stepath, M. Eisenacher, O. Kohlbacher, V. Gieselmann, D. Winter

The paper uses cross-linking mass spectrometry to identify protein structures and cargo associated with lysosomes and early endosomes, revealing tetrameric PPT1 and flotillin complexes.

bioRxiv · Jan 12, 2022 · PreprintBiochemistry

Minor deviations from randomness have huge repercussions on the functional structuring of sequence space

L. Weidmann, T. Dijkstra, O. Kohlbacher, A. N. Lupas

The paper compares the distribution of natural protein sequences to random models, finding that natural sequences are largely random in global sequence space when accounting for amino acid composition.

bioRxiv · Jun 27, 2021 · PreprintEvolutionary Biology

Global Analysis of the Mammalian MHC class I Immunopeptidome at the Organism-Wide Scale

P. Kubiniok, A. Marcu, L. Bichmann, L. Kuchenbecker, H. Schuster, D. Hamelin, J. Despault, K. Kovalchik, L. Wessling, O. Kohlbacher, S. Stevanovic, R. Hans-Georg, M. C. Neidert, I. Sirois, E. Caron

The paper analyzes the MHC class I immunopeptidome across human and mouse tissues, identifying tissue-specific and -independent peptide properties and hyperconserved protein sources.

bioRxiv · Sep 28, 2020 · PreprintImmunology

An innovative approach for HLA typing, molecular tumor testing and the validation of tumor exclusive antigens

M. Ghosh, L. Bichmann, J. Scheid, G. Gueler, H. Schuster, M. Di Marco, A. Marcu, M. Beyer, A. Nelde, L. K. Freudenmann, L. Muehlenbruch, M. W. Loeffler, O. Kohlbacher, H.-G. Rammensee, S. Stevanovic

The paper describes an innovative approach for HLA typing, molecular tumor testing, and validation of tumor-exclusive antigens but has been withdrawn by the authors.

bioRxiv · Jun 5, 2020 · PreprintImmunology

Neolithic genomes reveal a distinct ancient HLA allele pool and population transformation in Europe

A. Immel, C. Rinne, J. Meadows, R. Barquera, A. Szolek, F. Pierini, J. Susat, L. Boehme, J. Dose, J. Bonczarowska, C. Drummer, K. Fuchs, D. Ellinghaus, J. C. Kaessens, M. Furholt, , B. Krause-Kyora

The paper analyzes Neolithic genomes from Germany to show genetic heterogeneity and a high hunter-gatherer ancestry component in a WBC population, with distinct HLA allele pools related to viral immunity.

bioRxiv · Nov 21, 2019 · PreprintEvolutionary Biology