Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response
A. Chakravarthy, A. Furness, K. Joshi, E. Ghorani, K. Ford, M. J. Ward, E. V. King, M. Lechner, T. Marafioti, S. Quezada, G. J. Thomas, A. Feber, T. Fenton
This study identifies immune hot and cold tumour subgroups across cancers using DNA methylation-based deconvolution, linking them to immunotherapy response and immune resistance mechanisms.
bioRxiv · Mar 13, 2018Cancer Biology