T. Marafioti

Mitochondrial dsRNA from B-ALL cells stimulates mesenchymal stromal cells to become cancer associated fibroblasts

This study shows that mitochondrial dsRNA from B-ALL cells triggers MSC to become CAFs, linking genetic subtypes to survival outcomes.

Phenotyping of lymphoproliferative tumours generated in xenografts of non-small cell lung cancer

The paper identifies lymphoproliferative B cells in NSCLC PDX models and develops a tool for generating pathology overview figures.

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.

Exaggerated in vivo IL-17 responses discriminate recall responses in active TB

The paper shows that exaggerated IL-17A/F responses in active TB distinguish it from cured or latent TB, suggesting therapeutic targeting of this pathway.

Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations

The paper validates the use of CAL2 antibody for detecting CALR mutations in MPNs through immunohistochemistry and confirms its specificity to mutated CALR in ET and MDS/MPN.

Similar distribution of T-cell subsets in Crohn's disease and in diverticulitis provide evidence against a primary causal role for these cells in Crohn's

The study compares T-cell subset distribution in Crohn's disease and diverticulitis, finding no differences, suggesting T-cell accumulation is a secondary immune response rather than a primary cause of Crohn's.

Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

The paper investigates immune surveillance in pre-invasive squamous cell lung cancer, finding that regressive lesions have more immune infiltration and distinct molecular profiles compared to progressive lesions.

Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer

The paper analyzes genomic and transcriptomic data from CRC patients treated with cetuximab to identify resistance mechanisms and immune landscape changes during anti-EGFR therapy.

Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response

This study identifies immune hot and cold tumour subgroups across cancers using DNA methylation-based deconvolution, linking them to immunotherapy response and immune resistance mechanisms.