K. Ford

Discovery of SARS-CoV-2 papain-like protease (PLpro) inhibitors with efficacy in a murine infection model

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.

A Global Transcriptional Atlas of the Effect of Sleep Deprivation in the Mouse Frontal Cortex

This study presents a global transcriptional atlas of sleep deprivation effects in mouse frontal cortex using bulk and single-nuclear RNA sequencing, showing widespread transcriptional repression and isoform switching in glutamatergic neurons.

A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

This study identifies mTOR inhibition as a way to prevent adaptive resistance to CDK4/6 blockade in HNSCC by targeting cell cycle pathways.

Microtomographic investigation of a large corpus of cichlids

The paper describes a method for nondestructively imaging cichlids using micro-CT and presents morphological analyses of their jaws and skulls.

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering

The paper shows that c-Src-dependent phosphorylation of Mfn2 reduces ER-mitochondria distance and enhances Ca2+ transfer, affecting ROS and mitochondrial bioenergetics.

Mitochondrial uncoupling protein 2 (UCP2), but not UCP3, is sensitive to oxygen concentration in cells

This study investigates the sensitivity of UCP2 and UCP3 to oxygen concentration in different cellular models, finding UCP2 is sensitive while UCP3 is not.

Pan-cancer deconvolution of cellular composition identifies molecular correlates of antitumour immunity and checkpoint blockade response

This study identifies immune hot and cold tumour subgroups across cancers using DNA methylation-based deconvolution, linking them to immunotherapy response and immune resistance mechanisms.