Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism
A. Shi, M. M. G. Hillege, W. Noort, C. Offringa, G. Wu, T. Forouzanfar, W. M. H. Hoogaars, R. C. I. Wüst, R. T. Jaspers
This study shows that myofibre-specific knockout of TGF-β type I receptors in mice increases muscle mass, strength, and mitochondrial activity.
bioRxiv · Aug 30, 2023Physiology