Author

A. Shi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Cell Biology· 2 Microbiology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Approach:experimental assay· 7 Research Focus:differential expression· 5 Organism:human· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Approach:statistical model· 3

Frequent Co-Authors

G. Wu· 2 shared J. Sun· 2 shared M. Kellis· 2 shared R. T. Jaspers· 2 shared A. Chaudhri· 1 shared A. Hernandez-Ono· 1 shared A. Isaacs· 1 shared A. Jiang· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersPhysiology

G. Wu

Mutual co-authors in cluster

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11 papers

Recent·Most cited

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

J. Xu, Y. Liang, N. Li, S. Dang, A. Jiang, Y. Liu, Y. Guo, X. Yang, Y. Yuan, X. Zhang, Y. Yang, Y. Du, A. Shi, X. Liu, D. Li, K. He

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

bioRxiv · Jul 9, 2024Cell Biology

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

M. Dong, H. Lin, M. Pan, M. Huang, M. Liu, R. Jiang, Y. Lai, A. Shi, B. Yao, B. Hu, Z. Shi, A. Zhang, Y. Gao, W. Zeng, J. Li

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

bioRxiv · Feb 19, 2024 · PreprintImmunology

Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism

A. Shi, M. M. G. Hillege, W. Noort, C. Offringa, G. Wu, T. Forouzanfar, W. M. H. Hoogaars, R. C. I. Wüst, R. T. Jaspers

This study shows that myofibre-specific knockout of TGF-β type I receptors in mice increases muscle mass, strength, and mitochondrial activity.

bioRxiv · Aug 30, 2023Physiology

Functional interaction of torsinA and its activators in liver lipid metabolism

A. Hernandez-Ono, Y. P. Zhao, J. W. Murray, C. Ostlund, M. J. Lee, A. Shi, W. T. Dauer, H. J. Worman, H. N. Ginsberg, J.-Y. Shin

The paper shows that torsinA and its activators LAP1 and LULL1 regulate liver triglyceride secretion and steatosis in mice.

bioRxiv · Jun 21, 2023Cell Biology

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

M. Maitituoheti, A. Shi, M. Tang, L.-L. Ho, C. Terranova, K. Galani, E. Keung, C. Creasy, M. Wu, J. Chen, N. Chen, A. Singh, A. Chaudhri, N. Anvar, G. Tarantino, , K. Rai

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during Aging

Y. Wu, B. Zhu, R. Zhang, N. P. Goplen, X. Gao, H. Narasimhan, A. Shi, Y. Chen, Y. Li, H. Dong, T. J. Braciale, J. Sun

This study uses single-cell RNA sequencing to show that aged alveolar macrophages exhibit a senescence-like phenotype linked to reduced CBFβ expression and impaired self-renewal.

bioRxiv · Jun 4, 2022 · PreprintImmunology

Type IV pili is a critical virulence factor in clinical isolates of Paenibacillus thiaminolyticus

C. Hehnly, A. Shi, P. Ssentongo, L. Zhang, A. Isaacs, S. U. Morton, N. Streck, P. Erdmann-Gilmore, I. Tolstoy, R. R. Townsend, D. D. Limbrick, J. N. Paulson, J. E. Ericson, M. Y. Galperin, S. J. Schiff, J. R. Broach

The paper identifies type IV pili as a critical virulence factor in Paenibacillus thiaminolyticus clinical isolates associated with postinfectious hydrocephalus.

bioRxiv · Jan 24, 2022 · PreprintMicrobiology

Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SC) through the Galectin-9-Dependent Cell Contact Mechanism

W. Hu, X. Song, H. Yu, S. Fan, A. Shi, J. Sun, H. Wang, L. Zhao, Y. Zhao

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.

bioRxiv · Oct 7, 2021 · PreprintImmunology

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

M. Hillege, A. Shi, R. A. Galli, G. Wu, P. Bertolino, W. M. Hoogaars, R. T. Jaspers

This study shows that simultaneous knockout of Tgfbr1 and Acvr1b in muscle leads to hypertrophy and enhanced regeneration, but not when only one receptor is knocked out.

bioRxiv · Mar 3, 2021Physiology

Genetic diversity of the spinach downy mildew pathogen based on hierarchical sampling

C. Feng, K. Lamour, B. D. S. Dhillon, M. I. Villarroel-Zeballos, V. L. Castroagudin, B. H. Bluhm, A. Shi, A. Rojas, J. C. Correll

The paper analyzes genetic diversity in the spinach downy mildew pathogen Peronospora effusa using SNP loci from 67 isolates, revealing clonal and sexual reproduction strategies and population substructure.

bioRxiv · Feb 18, 2020 · PreprintMicrobiology

Plasma-derived exosomal analysis and deconvolution enables prediction and tracking of melanoma checkpoint blockade response

A. Shi, G. G. Kasumova, W. A. Michaud, J. Cintolo-Gonzalez, J. F. Ohmura, A. Mehta, I. Chien, D. T. Frederick, S. Cohen, D. Plana, D. Johnson, K. T. Flaherty, R. J. Sullivan, M. Kellis, G. M. Boland

This paper uses plasma-derived exosomal RNA to predict and track melanoma response to immune checkpoint inhibitors by analyzing tumor and immune signatures.

bioRxiv · Oct 18, 2019 · PreprintCancer Biology