R. T. Jaspers

Myofibre-specific knockout of TGF-β type I receptors triggers muscle hypertrophy and promotes contraction and oxidative metabolism

This study shows that myofibre-specific knockout of TGF-β type I receptors in mice increases muscle mass, strength, and mitochondrial activity.

MicroRNA-155 regulates osteogenesis and bone mass phenotype via targeting S1PR1 gene

This study shows miR155 inhibits osteogenesis and reduces bone mass by targeting S1PR1, suggesting miR155 inhibition could promote bone regeneration.

Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche

This study shows that muscle stem cells in their native niche experience mechanical deformation from myofiber stretch-shortening and respond with increased nitric oxide production and gene expression related to proliferation.

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

This study shows that simultaneous knockout of Tgfbr1 and Acvr1b in muscle leads to hypertrophy and enhanced regeneration, but not when only one receptor is knocked out.

Glycine receptor subunit-β -deficiency in a mouse model of spasticity results in attenuated physical performance, growth and muscle strength

This study examines spasticity in mice with a glycine receptor subunit-β deficiency, finding reduced physical performance, growth, and muscle strength, with age-related worsening of symptoms.