BiochemistrybioRxiv
Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
T. Dieudonne, S. A. Herrera, M. J. Laursen…·G. Lenoir
This study investigates the autoinhibition and regulation of ATP8B1, a lipid flippase, through functional studies and cryo-EM structure analysis, revealing the role of phosphoinositides and terminal segments in its activity.
DOI 10.7554/elife.75272