Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders
T. Dieudonne, S. A. Herrera, M. J. Laursen, M. Lejeune, C. Stock, K. Slimani, C. Jaxel, J. A. Lyons, C. Montigny, T. G. Pomorski, P. Nissen, G. Lenoir
This study investigates the autoinhibition and regulation of ATP8B1, a lipid flippase, through functional studies and cryo-EM structure analysis, revealing the role of phosphoinositides and terminal segments in its activity.
bioRxiv · Nov 3, 2021Biochemistry