High affinity interactions and signal transduction between Aβ oligomers and TREM2
C. B. Lessard, S. L. Malnik, Y. Zhou, T. B. Ladd, P. E. Cruz, Y. Ran, P. Chakrabaty, T. E. Mahan, D. M. Holtzman, J. D. Ulrich, M. Colonna, T. Golde
This study investigates the high-affinity interaction between TREM2 and Aβ oligomers, showing that AD-associated TREM2 variants have reduced signaling and internalization capacity.
bioRxiv · Feb 22, 2018Cell Biology