Myeloid cell mPGES-1 mediates inflammatory pain hypersensitivity in mice.
L. Chen, G. Yang, D. P. Cormode, A. Saigal, S. Madhavan, L. L. Mazaleuskaya, G. R. Grant, G. A. FitzGerald, T. Grosser
This study shows that myeloid cell mPGES-1 is the main source of PGE2 in inflammatory pain hypersensitivity in mice, suggesting it as a target for new pain therapies.
bioRxiv · Jan 31, 2020 · PreprintPharmacology & Toxicology