S. Madhavan

CameraEEG: Synchronized Recording of Video with Electroencephalogram data on an Android Application

CameraEEG synchronizes video and EEG data on an Android app, showing good temporal alignment and task identification through event markers.

APOL1 is not expressed in proximal tubules and is not filtered

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

Pyruvate oxidase as a key determinant of pneumococcal viability during transcytosis across the blood-brain barrier endothelium

This study identifies pyruvate oxidase (SpxB) as critical for pneumococcal survival during transcytosis across the blood-brain barrier by enabling acid tolerance and lysosomal enzyme inactivation.

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

This paper identifies structural changes in a non-hemolytic pneumolysin variant that disable pore formation, enabling pneumococcus to adopt an intracellular lifestyle with reduced inflammation and increased host tolerance.

Myeloid cell mPGES-1 mediates inflammatory pain hypersensitivity in mice.

This study shows that myeloid cell mPGES-1 is the main source of PGE2 in inflammatory pain hypersensitivity in mice, suggesting it as a target for new pain therapies.

Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer's Disease Brains

This study investigates human tau isoform aggregation in Alzheimer's disease, showing 3R tau aggregates faster than 4R and identifies key domains for aggregation, while demonstrating the use of RT-QuIC to detect misfolded tau.

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.