Nicotinamide mononucleotide (NMN) de-amidation by host-microbiome interactions
L.-J. Kim, T. J. Chalmers, R. Madawala, G. C. Smith, A. Das, E. W. K. Poon, J. Wang, S. P. Tucker, D. A. Sinclair, L.-E. Quek, L. E. Wu
This study shows orally delivered NMN undergoes deamidation and incorporation into mammalian tissue via the de novo pathway, with microbiome disruption reducing this process and increasing gut NAD+ availability.
bioRxiv · Sep 10, 2020Biochemistry