Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) modulates host phagocytic function.
T. J. Kim, B. J. Shenker, A. Macelroy, L. P. Walker, K. Boesze-Battaglia
This study shows that Aa Cdt toxin disrupts macrophage phagocytic function by altering phosphoinositide pools and Rab5 association, leading to reduced bactericidal capacity and increased bacterial survival.
bioRxiv · May 10, 2023 · PreprintImmunology