Author

T. J. Rettenmaier

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Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

D. A. Keedy· 1 shared E. Kang· 1 shared F. von DelftiD· 1 shared J. A. Wells· 1 shared J. Brandao-Neto· 1 shared J. S. Fraser· 1 shared J. T. Biel· 1 shared N. M. Pearce· 1 shared

Activity by Year

2017-2017 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

D. A. Keedy

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1 paper

Recent·Most cited

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

D. A. Keedy, Z. B. Hill, J. T. Biel, E. Kang, T. J. Rettenmaier, J. Brandao-Neto, N. M. Pearce, F. von Delft, J. A. Wells, J. S. Fraser

The paper identifies a new allosteric site in PTP1B using multitemperature crystallography and fragment screening, showing covalent tethering can inhibit enzyme activity.

bioRxiv · Nov 13, 2017Biophysics